Alkali metal cation release and respiratory inhibition induced by nigericin in rat liver mitochondria.
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منابع مشابه
Alkali metal cation release and respiratory inhibition induced by nigericin in rat liver mitochondria.
Nigericin is a monobasic acid antibiotic originally isolated by Harned et al.1' 2 The antibiotic analyzed for C39H69011 and the molecular weight of the sodium salt was found to be 736. Lardy et al.3 found nigericin and dianemycin to have the unusual property of inhibiting mitochondrial oxidation of glutamate and most other DPN-linked substrates and not inhibiting oxidation or phosphorylation wi...
متن کاملPotassium Ion-dependent hydrolysis of adenosine triphosphate induced by nigericin in mitochondria.
K+ is required for the stimulation by the antibiotic nigericin of adenosine triphosphate hydrolysis in rat liver mitochondria. This action does not occur when K+ is replaced by other monovalent cations. It requires slightly hypotonic conditions and is not related to the swelling phenomena linked to the accumulation of K+ in mitochondria. ATPase is inhibited by small anion molecules to which the...
متن کاملPotassium Ion-dependent Hydrolysis of Adenosine Triphosphate Induced by Nigericin in Mitochondria*
K+ is required for the stimulation by the antibiotic nigericin of adenosine triphosphate hydrolysis in rat liver mitochondria. This action does not occur when K+ is replaced by other monovalent cations. It requires slightly hypotonic conditions and is not related to the swelling phenomena linked to the accumulation of K+ in mitochondria. ATPase is inhibited by small anion molecules to which the...
متن کاملPotassium-specific Uncoupling by Nigericin*
The uncoupling activity of nigericin in rat liver mitochondria was found to be proportional to the external concentration of potassium. Rubidium (40% as effective as potassium) was the only other alkali metal cation that permitted significant uncoupling. The ability of nigericin selectively to inhibit (at low concentrations) and to uncouple (at high concentrations) only certain substrates was i...
متن کاملMechanism of alloxan-induced calcium release from rat liver mitochondria.
The objective of the present work was to investigate the mechanism of alloxan-induced Ca2+ release from rat liver mitochondria. Transport of Ca2+, oxidation and hydrolysis of mitochondrial pyridine nucleotides, changes in the mitochondrial membrane potential, and oxygen consumption by mitochondria were investigated. Alloxan does not inhibit the uptake of Ca2+ but stimulates the release of Ca2+ ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1966
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.56.2.654